Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 222)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0640196	0.1135584	0.5788893
Weighted median	23	0.0265995	0.0573136	0.6425729
Inverse variance weighted	23	0.0515174	0.0446085	0.2481399
Simple mode	23	-0.0001278	0.0892667	0.9988708
Weighted mode	23	0.0166076	0.0721364	0.8200446

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.17841	21	0.1650256
Inverse variance weighted	28.75968	22	0.1518507

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070951	0.0064188	0.2815097

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009243	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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