Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 221)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0689537	0.1141441	0.5522523
Weighted median	23	0.0247871	0.0573521	0.6656024
Inverse variance weighted	23	0.0108037	0.0439052	0.8056288
Simple mode	23	-0.0195618	0.1144217	0.8658158
Weighted mode	23	0.0807631	0.0862519	0.3592519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.45979	21	0.1561473
Inverse variance weighted	27.86036	22	0.1803554

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003571	0.006452	0.5857853

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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