Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 220)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1438021	0.1118835	0.2126879
Weighted median	23	-0.0247663	0.0551951	0.6536453
Inverse variance weighted	23	-0.0106742	0.0443924	0.8099806
Simple mode	23	-0.0450231	0.0919058	0.6290658
Weighted mode	23	-0.0524040	0.0634751	0.4179032

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.38237	21	0.1922428
Inverse variance weighted	28.48179	22	0.1602588

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081753	0.0063242	0.2101532

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008651	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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