Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 22)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0145447	0.0998201	0.8855410
Weighted median	23	-0.0457216	0.0561609	0.4155776
Inverse variance weighted	23	-0.0178166	0.0390155	0.6479195
Simple mode	23	0.0132853	0.1013704	0.8969215
Weighted mode	23	-0.0874699	0.0811840	0.2929618

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.67286	21	0.8832367
Inverse variance weighted	13.79692	22	0.9085298

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019873	0.0056423	0.728188

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004244	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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