Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 219)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1164472	0.1019809	0.2663682
Weighted median	23	-0.0590568	0.0561257	0.2926973
Inverse variance weighted	23	-0.0414388	0.0395312	0.2945213
Simple mode	23	-0.0862118	0.0892756	0.3447001
Weighted mode	23	-0.0769132	0.0608953	0.2197977

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.91886	21	0.4041989
Inverse variance weighted	22.58532	22	0.4254518

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046062	0.0057644	0.433189

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007186	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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