Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 218)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0907605	0.0998212	0.3735459
Weighted median	23	-0.0097072	0.0541383	0.8576993
Inverse variance weighted	23	-0.0120004	0.0390158	0.7584034
Simple mode	23	0.0055129	0.0876128	0.9503954
Weighted mode	23	-0.0023244	0.0591883	0.9690282

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.22553	21	0.9005193
Inverse variance weighted	14.47639	22	0.8837129

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063105	0.0056424	0.2760193

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004415	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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