Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 217)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0071501	0.0998207	0.9435747
Weighted median	23	-0.0135146	0.0561308	0.8097331
Inverse variance weighted	23	0.0385598	0.0390158	0.3229995
Simple mode	23	-0.0511651	0.0947708	0.5947014
Weighted mode	23	-0.0204711	0.0634015	0.7498351

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.56445	21	0.5489793
Inverse variance weighted	19.68132	22	0.6029665

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019289	0.0056423	0.7358564

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000626	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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