Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 216)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0941022	0.1176037	0.4325754
Weighted median	23	-0.0531383	0.0625749	0.3957724
Inverse variance weighted	23	-0.0629140	0.0449987	0.1620744
Simple mode	23	-0.1631384	0.1232455	0.1991980
Weighted mode	23	0.0125592	0.0921728	0.8928569

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.15070	21	0.1104301
Inverse variance weighted	29.26593	22	0.1374237

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019153	0.0066476	0.7760815

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009655	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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