Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 215)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0927079	0.0998206	0.3635741
Weighted median	23	-0.0277707	0.0560676	0.6203834
Inverse variance weighted	23	-0.0278569	0.0390157	0.4752322
Simple mode	23	-0.0383122	0.0909341	0.6776110
Weighted mode	23	-0.0442959	0.0664200	0.5117669

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.67336	21	0.7877138
Inverse variance weighted	16.17155	22	0.8072815

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039825	0.0056424	0.4880547

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005055	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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