Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 214)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0934269	0.1058189	0.3872891
Weighted median	23	0.0612701	0.0581158	0.2917564
Inverse variance weighted	23	0.0155413	0.0410197	0.7047823
Simple mode	23	0.0072760	0.0958534	0.9401784
Weighted mode	23	0.0621346	0.0657913	0.3552127

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.59992	21	0.3128442
Inverse variance weighted	24.31851	22	0.3307581

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004783	0.0059814	0.4328735

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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