Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 213)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1660522	0.0998196	0.1110610
Weighted median	23	0.0517678	0.0559709	0.3550151
Inverse variance weighted	23	0.0766821	0.0390154	0.0493643
Simple mode	23	-0.0560162	0.1046645	0.5978821
Weighted mode	23	0.1278931	0.0706045	0.0837546

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.95098	21	0.8716956
Inverse variance weighted	14.89711	22	0.8666153

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054883	0.0056423	0.3417772

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005685	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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