Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 212)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0190838	0.0998176	0.8502160
Weighted median	23	-0.0507156	0.0623674	0.4161175
Inverse variance weighted	23	-0.0452665	0.0390149	0.2459518
Simple mode	23	-0.0911100	0.1152900	0.4378074
Weighted mode	23	-0.1372337	0.1284645	0.2969847

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.30000	21	0.5023365
Inverse variance weighted	20.79055	22	0.5337126

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039518	0.0056422	0.4913679

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006708	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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