Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 211)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1697197	0.1079459	0.1308350
Weighted median	23	-0.0034117	0.0556431	0.9511095
Inverse variance weighted	23	-0.0556725	0.0459957	0.2261317
Simple mode	23	-0.0931507	0.1023708	0.3727189
Weighted mode	23	-0.0193035	0.0643531	0.7670218

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.55838	21	0.2667972
Inverse variance weighted	30.57627	22	0.1051175

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0138412	0.0061016	0.0339674

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009882	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8