Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 210)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0995076	0.0998197	0.3301746
Weighted median	23	-0.0999304	0.0585490	0.0878624
Inverse variance weighted	23	-0.0712818	0.0390154	0.0676975
Simple mode	23	-0.1279183	0.1018489	0.2223050
Weighted mode	23	-0.0946573	0.0734566	0.2109189

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.65438	21	0.8839824
Inverse variance weighted	13.74875	22	0.9101559

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017334	0.0056423	0.7617122

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005178	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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