Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 21)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0463893	0.0998212	0.6469114
Weighted median	23	-0.0406980	0.0537955	0.4493306
Inverse variance weighted	23	-0.0481482	0.0390158	0.2171768
Simple mode	23	-0.0132277	0.0899108	0.8843773
Weighted mode	23	-0.0213158	0.0628453	0.7376915

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.12614	21	0.7625226
Inverse variance weighted	17.18481	22	0.7530800

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058055	0.0056424	0.315224

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005669	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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