Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 209)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1532199	0.1026963	0.1505778
Weighted median	23	-0.1051388	0.0566586	0.0635026
Inverse variance weighted	23	-0.0299141	0.0407750	0.4631691
Simple mode	23	0.0663495	0.1116287	0.5583238
Weighted mode	23	-0.1566976	0.0777502	0.0562408

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.22844	21	0.3864500
Inverse variance weighted	24.02957	22	0.3456811

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075723	0.005805	0.2061952

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000746	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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