Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 208)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0092912	0.1017756	0.9281265
Weighted median	23	0.0525931	0.0551714	0.3404541
Inverse variance weighted	23	0.0898108	0.0398871	0.0243460
Simple mode	23	0.1118409	0.1014744	0.2823045
Weighted mode	23	0.0126084	0.0660599	0.8503832

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.83081	21	0.4093154
Inverse variance weighted	22.99420	22	0.4020572

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060858	0.0057528	0.3021267

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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