Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 207)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0832726	0.1343654	0.5420911
Weighted median	23	0.0594166	0.0554831	0.2842169
Inverse variance weighted	23	0.0678690	0.0513291	0.1860905
Simple mode	23	0.1899593	0.0960708	0.0606733
Weighted mode	23	0.0879813	0.0639950	0.1830307

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.05049	21	0.0127142
Inverse variance weighted	38.07859	22	0.0179533

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009459	0.0075949	0.9020672

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012455	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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