Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 206)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1100410	0.0998203	0.2827656
Weighted median	23	-0.0738185	0.0555474	0.1838717
Inverse variance weighted	23	-0.0357085	0.0390157	0.3600682
Simple mode	23	-0.0452956	0.0990909	0.6520727
Weighted mode	23	-0.0532906	0.0667474	0.4331781

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.66351	21	0.7312907
Inverse variance weighted	17.31803	22	0.7455706

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045648	0.0056423	0.4275747

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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