Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 205)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1275002	0.0998213	0.2154434
Weighted median	23	-0.0019013	0.0526601	0.9711980
Inverse variance weighted	23	-0.0340301	0.0390160	0.3830941
Simple mode	23	-0.0309861	0.0830875	0.7127670
Weighted mode	23	-0.0005337	0.0604749	0.9930383

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	7.785085	21	0.9959897
Inverse variance weighted	10.875814	22	0.9764754

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0099195	0.0056423	0.0933075

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003526	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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