Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 204)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0848961	0.0998207	0.4046482
Weighted median	23	0.0066821	0.0539858	0.9014936
Inverse variance weighted	23	-0.0214766	0.0390157	0.5820039
Simple mode	23	0.0195801	0.0919527	0.8333372
Weighted mode	23	0.0244840	0.0638976	0.7052664

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.11720	21	0.9044635
Inverse variance weighted	14.45755	22	0.8844480

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065323	0.0056423	0.2599712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004473	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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