Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 202)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.1130642 0.1278974 0.3866933
Weighted median 23 -0.0411192 0.0582152 0.4799818
Inverse variance weighted 23 0.0241453 0.0503956 0.6318564
Simple mode 23 -0.0275379 0.0953188 0.7753604
Weighted mode 23 -0.0275379 0.0650299 0.6760672

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 34.47566 21 0.0322077
Inverse variance weighted 36.70583 22 0.0254746

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0084259 0.0072293 0.256874

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0011238 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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