Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 200)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0089441	0.0998202	0.9294528
Weighted median	23	-0.0644798	0.0567292	0.2556948
Inverse variance weighted	23	-0.0164517	0.0390155	0.6732661
Simple mode	23	-0.0535283	0.0977281	0.5893940
Weighted mode	23	-0.0971751	0.0782455	0.2273411

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.39191	21	0.6870929
Inverse variance weighted	17.46831	22	0.7370057

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015596	0.0056423	0.7849413

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005347	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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