Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 20)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0458128	0.1096529	0.6803354
Weighted median	23	0.0301645	0.0548063	0.5820570
Inverse variance weighted	23	0.0237681	0.0419209	0.5707307
Simple mode	23	0.0819893	0.1045796	0.4414062
Weighted mode	23	0.0612852	0.0647069	0.3538652

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.34104	21	0.2326958
Inverse variance weighted	25.39860	22	0.2783955

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013538	0.0061981	0.8292141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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