Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 2)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0047632	0.1152243	0.9674168
Weighted median	23	0.0174015	0.0534574	0.7447871
Inverse variance weighted	23	-0.0286091	0.0440539	0.5160717
Simple mode	23	0.0144047	0.0792067	0.8573562
Weighted mode	23	0.0085283	0.0589001	0.8861927

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.98146	21	0.1406780
Inverse variance weighted	28.04882	22	0.1740691

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014644	0.006513	0.8242784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008662	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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