Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 199)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0094369	0.0998211	0.9255776
Weighted median	23	-0.0226710	0.0530676	0.6692266
Inverse variance weighted	23	-0.0171202	0.0390158	0.6608056
Simple mode	23	-0.0695168	0.0894904	0.4455447
Weighted mode	23	-0.0341068	0.0626191	0.5914584

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.11410	21	0.6417725
Inverse variance weighted	18.19765	22	0.6942077

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016309	0.0056423	0.7753847

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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