Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 198)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0532193	0.1083557	0.6284118
Weighted median	23	0.0554247	0.0539767	0.3045025
Inverse variance weighted	23	0.0624385	0.0426822	0.1435027
Simple mode	23	0.0855594	0.1036433	0.4179401
Weighted mode	23	0.0583907	0.0609406	0.3483949

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.74486	21	0.2583836
Inverse variance weighted	26.32942	22	0.2378074

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071025	0.0061248	0.2592121

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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