Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 197)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0109271	0.0998203	0.9138705
Weighted median	23	0.0085926	0.0559359	0.8779132
Inverse variance weighted	23	0.0127229	0.0390158	0.7443512
Simple mode	23	-0.0315270	0.0897101	0.7286076
Weighted mode	23	-0.0218007	0.0627498	0.7315756

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.79036	21	0.8333222
Inverse variance weighted	14.79074	22	0.8710608

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001103	0.0056423	0.9845909

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004514	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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