Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 196)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0926363	0.0998200	0.3639350
Weighted median	23	-0.0657048	0.0527011	0.2124918
Inverse variance weighted	23	-0.0348303	0.0390156	0.3720032
Simple mode	23	0.0357358	0.0799351	0.6592019
Weighted mode	23	-0.0661437	0.0634153	0.3082639

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.32400	21	0.8968521
Inverse variance weighted	13.71983	22	0.9111239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035499	0.0056423	0.5360352

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004399	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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