Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 195)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1739264	0.1193456	0.1598164
Weighted median	23	-0.0279476	0.0580373	0.6301285
Inverse variance weighted	23	-0.0234943	0.0475661	0.6213561
Simple mode	23	-0.0032749	0.1053677	0.9754857
Weighted mode	23	-0.0569494	0.0595363	0.3491892

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.01940	21	0.0915988
Inverse variance weighted	32.70011	22	0.0662187

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.009238	0.006746	0.1853389

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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