Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 194)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0999466	0.0998202	0.3280967
Weighted median	23	0.0142758	0.0595529	0.8105501
Inverse variance weighted	23	0.0435329	0.0390156	0.2645146
Simple mode	23	0.0076435	0.1090378	0.9447474
Weighted mode	23	0.0298228	0.0701385	0.6748220

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.75780	21	0.6006736
Inverse variance weighted	19.13479	22	0.6369908

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034644	0.0056423	0.5458131

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006176	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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