Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 193)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0044882	0.1212941	0.9708325
Weighted median	23	0.0610225	0.0620620	0.3254841
Inverse variance weighted	23	-0.0194624	0.0463697	0.6746885
Simple mode	23	0.0705515	0.1341116	0.6041056
Weighted mode	23	0.1013180	0.0868895	0.2560779

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.00851	21	0.0735165
Inverse variance weighted	31.07646	22	0.0945615

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014708	0.0068562	0.8322079

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009492	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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