Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 192)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0434485	0.1069973	0.6887987
Weighted median	23	-0.0066112	0.0538654	0.9023160
Inverse variance weighted	23	-0.0339696	0.0414561	0.4125524
Simple mode	23	-0.0291636	0.0793908	0.7168734
Weighted mode	23	-0.0069915	0.0567091	0.9029995

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.12822	21	0.2868873
Inverse variance weighted	24.83820	22	0.3048747

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047542	0.006048	0.4405989

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007756	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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