Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 191)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0606482	0.0998209	0.5499868
Weighted median	23	0.0854099	0.0549367	0.1200181
Inverse variance weighted	23	0.0528650	0.0390159	0.1754303
Simple mode	23	0.0920482	0.0808528	0.2671720
Weighted mode	23	0.0793619	0.0615568	0.2107034

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.20362	21	0.9586733
Inverse variance weighted	11.21079	22	0.9716107

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000478	0.0056424	0.9332938

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003954	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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