Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 19)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0347933	0.1026917	0.7381149
Weighted median	23	0.0123025	0.0562581	0.8269002
Inverse variance weighted	23	-0.0382030	0.0397679	0.3367291
Simple mode	23	-0.0074511	0.0993645	0.9409020
Weighted mode	23	0.0019877	0.0599634	0.9738544

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.22535	21	0.3866252
Inverse variance weighted	22.85654	22	0.4098682

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0044827	0.0058046	0.4485638

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007217	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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