Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 189)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1739459	0.1107004	0.1310539
Weighted median	23	0.0494910	0.0567138	0.3828572
Inverse variance weighted	23	0.0568312	0.0435828	0.1922396
Simple mode	23	0.0886195	0.0829840	0.2971397
Weighted mode	23	0.0703304	0.0617748	0.2671599

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.82765	21	0.213097
Inverse variance weighted	27.45241	22	0.194545

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007192	0.0062573	0.2633238

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8