Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 188)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0330198	0.0998201	0.7440787
Weighted median	23	0.0468139	0.0557925	0.4014290
Inverse variance weighted	23	0.0183554	0.0390157	0.6380260
Simple mode	23	0.0404507	0.0852728	0.6399124
Weighted mode	23	0.0678915	0.0635872	0.2972359

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.84044	21	0.7785483
Inverse variance weighted	15.86591	22	0.8224845

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009005	0.0056423	0.8747172

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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