Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 186)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0934969	0.1033322	0.3758254
Weighted median	23	0.0537442	0.0556156	0.3338685
Inverse variance weighted	23	0.0535146	0.0396252	0.1768491
Simple mode	23	0.0599918	0.0785293	0.4530181
Weighted mode	23	0.0626929	0.0565306	0.2794033

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.50351	21	0.3710095
Inverse variance weighted	22.69288	22	0.4192417

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024553	0.0058408	0.6784855

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007447	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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