Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 185)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1447640	0.0998202	0.1617622
Weighted median	23	0.0615307	0.0550406	0.2636037
Inverse variance weighted	23	0.0267522	0.0390154	0.4929126
Simple mode	23	-0.0733529	0.1011084	0.4758000
Weighted mode	23	0.0951465	0.0691950	0.1829593

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.81776	21	0.5968294
Inverse variance weighted	20.46749	22	0.5538224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072471	0.0056423	0.2129851

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006345	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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