Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 184)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2351738	0.1119380	0.0478986
Weighted median	23	0.0059567	0.0603713	0.9214023
Inverse variance weighted	23	0.0038184	0.0476019	0.9360658
Simple mode	23	-0.0813229	0.1227260	0.5144451
Weighted mode	23	0.0336229	0.0810219	0.6821720

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.40907	21	0.1912787
Inverse variance weighted	32.74977	22	0.0654815

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0142076	0.0063273	0.0356326

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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