Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 183)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0508400	0.0998209	0.6158435
Weighted median	23	-0.0509732	0.0555115	0.3584898
Inverse variance weighted	23	-0.0084235	0.0390158	0.8290663
Simple mode	23	-0.0500193	0.0909002	0.5876813
Weighted mode	23	-0.0446444	0.0702144	0.5314466

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.62893	21	0.7333397
Inverse variance weighted	17.04496	22	0.7608754

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036394	0.0056424	0.5259064

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005179	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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