Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 182)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0173022	0.1139002	0.8807107
Weighted median	23	0.0118320	0.0621070	0.8489090
Inverse variance weighted	23	0.0175248	0.0436093	0.6877870
Simple mode	23	0.0253444	0.1082222	0.8170040
Weighted mode	23	0.0253444	0.0726977	0.7306829

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.34234	21	0.1598070
Inverse variance weighted	27.48602	22	0.1933457

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021387	0.0064382	0.7430363

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000839	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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