Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 181)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0489023	0.1225350	0.6938577
Weighted median	23	0.0207243	0.0673010	0.7581317
Inverse variance weighted	23	0.0071371	0.0470673	0.8794737
Simple mode	23	0.1659888	0.1408068	0.2510544
Weighted mode	23	0.0601058	0.0858571	0.4912223

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.64586	21	0.0635605
Inverse variance weighted	32.01788	22	0.0770917

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034414	0.0069263	0.6244501

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009712	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8