Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 180)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0838692	0.1020924	0.4205890
Weighted median	23	0.0503944	0.0566463	0.3736633
Inverse variance weighted	23	0.0188567	0.0400801	0.6380145
Simple mode	23	0.0773024	0.0990273	0.4433467
Weighted mode	23	0.0422344	0.0622433	0.5045073

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.96694	21	0.4014171
Inverse variance weighted	23.21698	22	0.3895656

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063084	0.0057707	0.286703

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007106	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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