Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 18)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1002837	0.0998209	0.3265088
Weighted median	23	0.0584232	0.0529832	0.2701687
Inverse variance weighted	23	0.0339619	0.0390157	0.3840446
Simple mode	23	0.0456964	0.0832083	0.5884129
Weighted mode	23	0.0647687	0.0605459	0.2963304

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.16415	21	0.8624455
Inverse variance weighted	14.68519	22	0.8753903

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040728	0.0056424	0.4783616

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000468	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8