Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 179)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1298202	0.1023261	0.2184348
Weighted median	23	0.0361180	0.0574908	0.5298469
Inverse variance weighted	23	0.0186114	0.0403518	0.6446348
Simple mode	23	0.0780059	0.0986128	0.4373710
Weighted mode	23	0.0605023	0.0598062	0.3227083

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.06757	21	0.3956248
Inverse variance weighted	23.53258	22	0.3721981

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068293	0.005784	0.2509092

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00072	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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