Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 178)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0468187	0.0998202	0.6438807
Weighted median	23	0.0541484	0.0542784	0.3184710
Inverse variance weighted	23	0.0376328	0.0390155	0.3347648
Simple mode	23	0.1063481	0.1032483	0.3141910
Weighted mode	23	0.0704463	0.0702547	0.3268948

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.01549	21	0.5202805
Inverse variance weighted	20.02548	22	0.5814457

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005641	0.0056423	0.9213105

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000635	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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