Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 177)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0420890	0.0998209	0.6775685
Weighted median	23	-0.0368321	0.0522965	0.4812501
Inverse variance weighted	23	-0.0311575	0.0390156	0.4245286
Simple mode	23	-0.0194043	0.0901608	0.8315796
Weighted mode	23	-0.0401270	0.0629198	0.5302202

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.62630	21	0.7902665
Inverse variance weighted	15.64046	22	0.8333204

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006713	0.0056423	0.9064251

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004933	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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