Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 176)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1444073	0.1061311	0.1880503
Weighted median	23	-0.0673409	0.0547996	0.2191254
Inverse variance weighted	23	-0.0433626	0.0415480	0.2966354
Simple mode	23	-0.0530674	0.0812430	0.5203998
Weighted mode	23	-0.0735719	0.0647642	0.2681819

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.73932	21	0.3058600
Inverse variance weighted	24.94877	22	0.2995309

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062051	0.005999	0.3127352

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007934	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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