Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 175)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0798464	0.0998205	0.4327248
Weighted median	23	0.0493704	0.0558343	0.3765712
Inverse variance weighted	23	0.0358403	0.0390155	0.3582969
Simple mode	23	0.0721454	0.0959024	0.4598569
Weighted mode	23	0.0351020	0.0814352	0.6706316

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.08394	21	0.7060056
Inverse variance weighted	17.31333	22	0.7458364

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027024	0.0056423	0.6369217

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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